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These alterations enhance signals such as GLP-1 [263, 264] reshaping appetite, reward processing, and glycemic control, earning SG and RYGB the label metabolic surgeries. The concept of surgically treating obesity traces back to mid-20th-century observations that patients who underwent partial/total gastrectomy for ulcers or cancer often shed substantial weight [265]
Seiler T et al
Combined, these medicines have a complementary effect on type 2 diabetes management
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